Journal of Skin and Stem Cell
Volume:3 Issue: 2, Jun 2016

Leishmaniasis is one of the most common parasitic diseases. Many medicinal plants have been utilized for the treatment of leishmaniasis.

 Recent clinical trials have proven the efficacy of a number of herbal drugs. Synthetic agents and current drugs on the market have some disadvantages, such as side effects, high cost, and painful injections. Given the efficiency of herbal drugs, they can be a source of natural and harmless compounds for Leishmania treatment.

Several researches have shown a wide range of plant extract exhibiting remarkable anti-leishmanial activity in vitro and in vivo.

Attempts for discovery of an effective strategy for leishmaniasis treatment with nominal side effects are being continued and herbal drugs are receiving much interest. More clinical studies should be done to investigate the efficacy and safety of herbal drugs for the production of effective and safe drugs for leishmaniasis treatment. This may also provide new hope for leishmaniasis treatment.

Psoriasis is one of the most common skin diseases with prevalence rate of 1.4% to 2.9%. The scalp type of this disease is also common. This study was conducted to compare the efficacy and drug complications of single and combination regimens.

Fifty-four patients with scalp psoriasis were randomly divided to 2 groups. In one group (n = 27) betamethasone and calcipotriol (B + C) were administered simultaneously and in the other group (n = 23) betamethasone was administered alone. Clinical status of patients before the treatment, baseline, and 8 weeks after treatment were compared in both groups based on TSS, IGA, and PGA scores.

The goal of this study was to evaluate Tss < 1, absence of disease based on IGA, and cleared disease according to PGA. The intensity of the clinical symptoms based on IGA was significantly better in the combination therapy group compared with the monotherapy group at the end of the treatment (P value of 0.04). Furthermore, patients of the calcipotriol group reached a better status compared to the control group (P value of 0.007). Comparison of the basic TSS and TSS at eight weeks showed a significant difference between the two groups after termination of the treatment (P = 0.004).

It could be concluded that combination therapy is a reliable and low-complication method compared with the single-drug regimen and is more effective with better efficacy

Wet cupping therapy has been used in many ancient societies for thousands of years yet there are few systematic studies and clinical researches in this field. This technique can be used for several skin disorders, including hair loss, hirsutism, acne, urticaria, psoriasis, and herpes zoster. A metabonomic study with mass spectrometry was used for the first time to evaluate the difference between wet cupping blood and venous blood.

The metabolites of the wet cupping blood and venous blood were compared in 20 healthy individuals using a metabonomics technique.

Using various modeling techniques, such as OSC-PLS, 17 differentiating metabolites were detected and identified by the Human Metabolome Database and 16 differentiating pathways were recognized with Metaboanalyst between the 2 kinds of blood, including cholesterol, cortisone, aldosterone, primary bile acids, L-arginine, taurine, hypotaurine, D-glucose, and pyridoxamine.

Cupping blood and venous blood seemed to differ greatly in terms of metabolites and 16 differentiating metabolite pathways. This technique can be used for several skin disorders, including hair loss, hirsutism, acne, urticaria, psoriasis, and herpes zoster

Lichen Planus (LP) is an inflammatory disease with different clinical manifestations.

This study presents a fairly uncommon form of lichen planus following the lines of Blaschko. The lesions were in a whorled pattern on the right side of the trunk with extension to infra-mammary fold and discrete red-to-violaceous lichenoid papules without linear distribution on the left side of the trunk.

An uncommon form of lichen planus is presented that every dermatologist should keep in mind on observing a dermatosis with a Blaschko linear pattern of distribution

Melasma is a common pigmentary disorder with the incidence of 1.5% - 33.3% worldwide. Targeting the vascular component in melasma lesions may decrease the melanocytic stimulation. Herbal anticoagulants can serve as effective candidates for melasma treatment.

The evidence was gathered in this study by evaluating vascularization as an etiology of melasma and considering the role of herbal anticoagulants in natural vascular treatment. Databases such as PubMed and Scopus were screened and the following keywords were searched: melasma, vascularization, pigmentation, and herbal anticoagulant. These subjects were further investigated in traditional textbooks such as the canon of medicine by Avicenna and Alhavi by Razi. At the end, the results were discussed.

The use of anticoagulants can reduce the clot formation and lower the VEGF release. In this way, vascularization will be reduced, consequently leading to a decrease in melasma occurrence. The researchers of the present study went over the herbal components that were effective for treatment of melasma and found that most of them consisted of anticoagulants such as coumarin.

The effect of herbal anticoagulants (administered orally) on melasma should be evaluated clinically and their combination with topical treatments is suggested